Article
Novel attenuated Salmonella enterica serovar Choleraesuis strains as live vaccine candidates generated by signature-tagged mutagenesis.
Infection and immunity - 1 Dec 2005
Ku Yu-We, McDonough Sean P, Palaniappan Raghavan U M, Chang Chao-Fu, Chang Yung-Fu
Abstract excerpt
Salmonella enterica serovar Choleraesuis is a host-adapted pathogen that causes swine paratyphoid. Signature-tagged mutagenesis (STM) was used to understand the pathogenicity of S. enterica serovar Choleraesuis in its natural host and also to develop novel attenuated live vaccine candidates against this disease. A library of 960 signature-tagged mutants of S. enterica serovar Choleraesuis was constructed and...
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