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Article

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.

Neurobiology of aging - 1 Jan 2000

Colton Carol A, Brown Candice M, Cook Danielle, Needham Leila K, Xu Qing, Czapiga Meggan, Saunders Ann M, Schmechel Donald E, Rasheed Karima, Vitek Michael P

Abstract excerpt

The mechanism linking the APOE4 gene with increased susceptibility for Alzheimer's disease (AD) and poorer outcomes following closed head injury and stroke is unknown. One potential link is activation of the innate immune system in the CNS. Our previously published data demonstrated that apolipoprotein E regulates production of nitric oxide, a critical cytoactive factor released by immune active macrophages. To...

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Source

Identifiers

PMID: 12392781
DOI: 10.1016/s0197-4580(02)00016-7

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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