Article
Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.
Neurobiology of disease - 1 Feb 2003
Ophir Gal, Meilin Sigal, Efrati Margalit, Chapman Joab, Karussis Dimitri, Roses Allen, Michaelson Daniel M
Abstract excerpt
The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer's disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele. In the present study, we employed mice transgenic for the human apoE isoforms apoE3 or apoE4 on a null mouse apoE background and intracerebroventricular injection of LPS to investigate the possibility...
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