Article
The Association of MME microRNA Binding Site Polymorphism with the Risk of Late Onset Alzheimer's Disease in Northern Han Chinese.
Current neurovascular research - 1 Jan 2017
Liu Chun-Xia, Tan Lin, Sun Fu-Rong, Zhang Wei, Miao Dan, Tan Meng-Shan, Wan Yu, Tan Chen-Chen, Yu Jin-Tai, Tan Lan
Abstract excerpt
BACKGROUND: Although β-amyloid (Aβ) degradation has been normally implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) through cellular biological studies, the genetic studies linking Aβ degradation and LOAD are still scarce. Neprilysin (NEP), one of the most crucial Aβ-degrading enzymes in AD, is the metalloendopeptidase which particularly participates in the monomeric Aβ species degradation....
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