p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.

doi:10.1371/journal.pbio.0020242

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Article

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.

PLoS biology - 1 Aug 2004

Kelly-Spratt Karen S, Gurley Kay E, Yasui Yutaka, Kemp Christopher J

Abstract excerpt

Ectopic expression of oncogenes such as Ras induces expression of p19(Arf), which, in turn, activates p53 and growth arrest. Here, we used a multistage model of squamous cell carcinoma development to investigate the functional interactions between Ras, p19(Arf), and p53 during tumor progression i...

Topics

9,10-Dimethyl-1,2-benzanthracene
Alleles
Animals
Carcinogens
Carcinoma, Squamous Cell
Crosses, Genetic
Cyclin-Dependent Kinase Inhibitor p16
Disease Progression
Genes, ras
Genotype
Loss of Heterozygosity
Lymphatic Metastasis
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Neoplasm Metastasis
Neoplasm Transplantation

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Identifiers

PMID: 15314658
DOI: 10.1371/journal.pbio.0020242
PMCID: PMC509304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15314658-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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