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Article

Differential p53-Independent Outcomes of p19 Arf Loss in Oncogenesis

18 Aug 2009

Abstract excerpt

One reported function of the tumor suppressor p19(Arf) is to stabilize p53, providing a critical checkpoint in the response to oncogenic insults. Acute loss of Pten leads to an increase in the abundance of p19(Arf), p53, and p21 proteins as part of a fail-safe senescence response. Here, we report that loss of p19(Arf) in prostate epithelium does not accelerate-but rather partially inhibits-the prostate cancer...

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PMID: 19690330
DOI: 10.1126/scisignal.2000053

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