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Article

Cdh1-APC controls axonal growth and patterning in the mammalian brain.

Science (New York, N.Y.) - 13 Feb 2004

Konishi Yoshiyuki, Stegmüller Judith, Matsuda Takahiko, Bonni Shirin, Bonni Azad

Abstract excerpt

The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown. We report that the inhibition of Cdh1-APC in primary neurons specifically enhanced axonal growth. Cdh1 knockdown in cerebellar slice overlay assays and in the developing rat cerebellum in vivo revealed cell-autonomous abnormalities in layer-specific growth of granule...

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Identifiers

PMID: 14716021
DOI: 10.1126/science.1093712

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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