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Article

APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.

Current biology : CB - 23 Nov 2004

Shi Song-Hai, Cheng Tong, Jan Lily Yeh, Jan Yuh-Nung

Abstract excerpt

In developing hippocampal neurons in culture, the evolutionarily conserved polarity complex mPar3/mPar6/aPKC selectively accumulates at the tip of one, and only one, of the immature neurites of a neuron and thus specifies the axon and generates neuronal polarity. How mPar3/mPar6 is enriched at the tip of the nascent axon, but not the dendrites, is not fully understood. Here, we report that mPar3 forms a complex...

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Source

Identifiers

PMID: 15556865
DOI: 10.1016/j.cub.2004.11.009

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.PMID 15556865Read ↗

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