Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.

Molecular and cellular neurosciences - 1 Jan 2014

Kowalski Jennifer R, Dube Hitesh, Touroutine Denis, Rush Kristen M, Goodwin Patricia R, Carozza Marc, Didier Zachary, Francis Michael M, Juo Peter

Abstract excerpt

Regulation of both excitatory and inhibitory synaptic transmission is critical for proper nervous system function. Aberrant synaptic signaling, including altered excitatory to inhibitory balance, is observed in numerous neurological diseases. The ubiquitin enzyme system controls the abundance of many synaptic proteins and thus plays a key role in regulating synaptic transmission. The Anaphase-Promoting Complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GABAergic Neurons

Share to gamma-Aminobutyric Acid

Share to Intercellular Signaling Peptides and Proteins

Share to Motor Neurons

Share to Neuromuscular Junction

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 24321454
DOI: 10.1016/j.mcn.2013.12.001
PMCID: PMC4036811

Genes

APC
CDC16
EMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.PMID 24321454Read ↗

Independent regulation of synaptic size and activity by the anaphase-promoting complex.Semantic proximity Read ↗

The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.Semantic proximity Read ↗

Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.Semantic proximity Read ↗

LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction.Semantic proximity Read ↗

The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans.Semantic proximity Read ↗

The ubiquitin ligase UBR-1 regulates the synaptic strength between the GABAergic and glutamatergic signalingSemantic proximity Read ↗

RSY-1 is a local inhibitor of presynaptic assembly in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans intersectin: a synaptic protein regulating neurotransmission.Semantic proximity Read ↗

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repressionSemantic proximity Read ↗

Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions.Semantic proximity Read ↗

An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.