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Article

Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Nov 2013

Wise Alexandria, Schatoff Emma, Flores Julian, Hua Shao-Ying, Ueda Atsushi, Wu Chun-Fang, Venkatesh Tadmiri

Abstract excerpt

The assembly of functional synapses requires the orchestration of the synthesis and degradation of a multitude of proteins. Protein degradation and modification by the conserved ubiquitination pathway has emerged as a key cellular regulatory mechanism during nervous system development and function (Kwabe and Brose, 2011). The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit ubiquitin ligase complex...

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Identifiers

PMID: 23933137
DOI: 10.1016/j.ijdevneu.2013.07.002
PMCID: PMC3831508

Genes

APC
APC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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