Article
APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
Molecular cell - 6 Jan 2022
Ferguson Cole J, Urso Olivia, Bodrug Tatyana, Gassaway Brandon M, Watson Edmond R, Prabu Jesuraj R, Lara-Gonzalez Pablo, Martinez-Chacin Raquel C, Wu Dennis Y, Brigatti Karlla W, Puffenberger Erik G, Taylor Cora M, Haas-Givler Barbara, Jinks Robert N, Strauss Kevin A, Desai Arshad, Gabel Harrison W, Gygi Steven P, Schulman Brenda A, Brown Nicholas G, Bonni Azad
Abstract excerpt
Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3 ubiquitin ligase anaphase promoting complex (APC). In mechanistic studies, we uncover a critical role for APC7 during the recruitment and ubiquitination of APC substrates. In proteomics analyses of the brain...
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