Article
Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation.
Cell and tissue research - 1 Sept 2009
Pan Ning, Jahan Israt, Lee Jacqueline E, Fritzsch Bernd
Abstract excerpt
Neurod1 is a crucial basic helix-loop-helix gene for most cerebellar granule cells and mediates the differentiation of these cells downstream of Atoh1-mediated proliferation of the precursors. In Neurod1 null mice, granule cells die throughout the posterior two thirds of the cerebellar cortex during development. However, Neurod1 is also necessary for pancreatic beta-cell development, and therefore Neurod1 null...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Body Weight
- Cell Differentiation
- Cerebellum
- Cytoplasmic Granules
- Disease Models, Animal
- Down-Regulation
- Genotype
- Immunohistochemistry
- Mice
- Mice, Knockout
- Promoter Regions, Genetic