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Article

piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.

Developmental cell - 1 Feb 2008

Schuldiner Oren, Berdnik Daniela, Levy Jonathan Ma, Wu Joy S, Luginbuhl David, Gontang Allison Camille, Luo Liqun

Abstract excerpt

Developmental axon pruning is widely used to refine neural circuits. We performed a mosaic screen to identify mutations affecting axon pruning of Drosophila mushroom body gamma neurons. We constructed a modified piggyBac vector with improved mutagenicity and generated insertions in >2000 genes. We identified two cohesin subunits (SMC1 and SA) as being essential for axon pruning. The cohesin complex maintains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18267091
DOI: 10.1016/j.devcel.2007.11.001
PMCID: PMC2268086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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