Article

Impaired migration and premature differentiation underlie the neurological phenotype associated with PCDH12 loss of function

2023-01-05

Abstract excerpt

<h4>Summary</h4> Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential neurodevelopmental processes related to neuronal maturation, dendritic arbor formation, axon pathfinding, and synaptic plasticity. Bi-allelic loss-of-function variants in PCDH12 are associated with several neurodevelopmental disorders (NDDs) such as diencephalic-mesencephalic dysplasia syndrome, cerebral palsy, cereb...

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Literature Corpus work: 79f9499a-c268-57a9-8493-497656b9bea8
DOI: 10.1101/2023.01.05.522934

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