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Article

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.

Journal of biological rhythms - 1 Feb 2008

Sekine Tatsumori, Yamaguchi Terumi, Hamano Kunikatsu, Young Michael W, Shimoda Masami, Saez Lino

Abstract excerpt

Double-time (dbt) is a casein kinase gene involved in cell survival, proliferation, and circadian rhythms in the fruit fly, Drosophila melanogaster. Genetic and biochemical studies have shown that dbt and its mammalian ortholog casein kinase I epsilon (hckI epsilon) regulate the circadian phosphorylation of period (per), thus controlling per subcellular localization and stability. Mutations in these kinases can...

Topics

Alleles
Animals
Animals, Genetically Modified
Behavior, Animal
Biological Evolution
Casein Kinase 1 epsilon
Circadian Rhythm
Conserved Sequence
Drosophila
Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Genes, Lethal

Germ-Line Mutation

Humans

Immunohistochemistry

Larva

Motor Activity

Phenotype

Source

Identifiers

PMID: 18258753
DOI: 10.1177/0748730407311652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18258753-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.PMID 18258753Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

Casein kinase I: another cog in the circadian clockworks.Semantic proximity Read ↗

The circadian clock-containing photoreceptor cells in Xenopus laevis express several isoforms of casein kinase I.Semantic proximity Read ↗

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity.Semantic proximity Read ↗

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