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Article

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.

Cell - 10 Jul 1998

Price J L, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young M W

Abstract excerpt

We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short- (dbtS) and long-period (dbtL) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbtP, causes pupal lethality and eliminates circadian cycling of per and tim gene products in larvae. In dbtP mutants, PER proteins constitutively...

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Source

Identifiers

PMID: 9674430
DOI: 10.1016/s0092-8674(00)81224-6

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.PMID 9674430Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.Semantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

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