Article
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.
Cell - 10 Jul 1998
Price J L, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young M W
Abstract excerpt
We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short- (dbtS) and long-period (dbtL) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbtP, causes pupal lethality a...
Topics
- Alleles
- Animals
- Biological Clocks
- Brain
- Circadian Rhythm
- DNA Transposable Elements
- Darkness
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Genes, Insect
- Insect Proteins
- Larva
- Light
- Mutagenesis
- Nuclear Proteins
- Period Circadian Proteins
- RNA, Messenger