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Article

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 2000

Suri V, Hall J C, Rosbash M

Abstract excerpt

Phosphorylation is an important feature of pacemaker organization in Drosophila. Genetic and biochemical evidence suggests involvement of the casein kinase I homolog doubletime (dbt) in the Drosophila circadian pacemaker. We have characterized two novel dbt mutants. Both cause a lengthening of behavioral period and profoundly alter period (per) and timeless (tim) transcript and protein profiles. The PER profile...

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Identifiers

PMID: 11027213
PMCID: PMC6772888

Genes

DBT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.PMID 11027213Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

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