Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.

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Article

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 2000

Suri V, Hall J C, Rosbash M

Abstract excerpt

Phosphorylation is an important feature of pacemaker organization in Drosophila. Genetic and biochemical evidence suggests involvement of the casein kinase I homolog doubletime (dbt) in the Drosophila circadian pacemaker. We have characterized two novel dbt mutants. Both cause a lengthening of behavioral period and profoundly alter period (per) and timeless (tim) transcript and protein profiles. The PER profile...

Topics

Alleles
Animals
Biological Clocks
Casein Kinase 1 epsilon
Circadian Rhythm
Darkness
Drosophila
Drosophila Proteins
Feedback
Gene Expression Regulation
Insect Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Light

Nuclear Proteins

Period Circadian Proteins

Phosphorylation

Protein Kinases

RNA, Messenger

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 11027213
PMCID: PMC6772888

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11027213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.PMID 11027213Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

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