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Article

Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA

29 Dec 2003

Abstract excerpt

Immune cells respond to chemotactic signals by means of G protein-coupled receptors. Attempts to elucidate the function of specific G protein family members in these responses is complicated by redundancy among the different G protein isoforms. We have used lentiviral-based RNA interference to eliminate expression of specific G protein subunits selectively in J774A.1 mouse macrophages. The chemotactic response to...

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PMID: 14699051
DOI: 10.1073/pnas.0307549100

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