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Article

Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival.

Molecular immunology - 1 Dec 2009

Lattin Jane E, Greenwood Kathryn P, Daly Norelle L, Kelly Gregory, Zidar David A, Clark Richard J, Thomas Walter G, Kellie Stuart, Craik David J, Hume David A, Sweet Matthew J

Abstract excerpt

The beta-arrestins (ARRB1 and ARRB2) regulate G-protein coupled receptor (GPCR) dependent- and independent-signaling pathways and are ubiquitously expressed. Here we show that ARRB2 mRNA and protein expression is enriched in macrophages, and that it regulates complement C1q expression and cell survival. Basal and Toll-like receptor (TLR) inducible expression of mRNAs encoding the complement subcomponents C1qa,...

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Identifiers

PMID: 19783052
DOI: 10.1016/j.molimm.2009.09.012

Genes

ARRB2
ARRB1

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