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Article

Complement component 5a receptor oligomerization and homologous receptor down-regulation.

The Journal of biological chemistry - 7 Nov 2008

Rabiet Marie-Josèphe, Huet Emilie, Boulay François

Abstract excerpt

Most G-protein-coupled receptors (GPCRs) form di(oligo)-meric structures that constitute signaling and trafficking units and might be essential for receptor functions. Cell responses to complement C5a receptor (C5aR) are tightly controlled by receptor desensitization and internalization. To examine the implication of dimerization in C5aR regulation, we generated an NH(2)-terminally modified C5aR mutant, unable to...

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Identifiers

PMID: 18772131
DOI: 10.1074/jbc.M805260200
PMCID: PMC2662174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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