Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

26 Aug 2019

Abstract excerpt

Neutrophil migration is essential for inflammatory responses to kill pathogens; however, excessive neutrophilic inflammation also leads to tissue injury and adverse effects. To discover novel therapeutic targets that modulate neutrophil migration, we performed a neutrophil-specific microRNA (miRNA) overexpression screen in zebrafish and identified 8 miRNAs as potent suppressors of neutrophil migration. Among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Immune cells in cancer
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31451657
DOI: 10.1073/pnas.1905221116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migrationPMID 31451657Read ↗

Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophilsSemantic proximity Read ↗

Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation stateSemantic proximity Read ↗

Inducible overexpression of zebrafish <i>microRNA-722</i> suppresses chemotaxis of human neutrophil like cellsSemantic proximity Read ↗

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafishSemantic proximity Read ↗

Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.Semantic proximity Read ↗

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.Semantic proximity Read ↗

RORA regulates neutrophil migration and activation in zebrafishSemantic proximity Read ↗

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.Semantic proximity Read ↗

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish.Semantic proximity Read ↗

Chemokine Receptors and Phagocyte Biology in ZebrafishSemantic proximity Read ↗

Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migrationSemantic proximity Read ↗

Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.