Article
Molecular genetic analysis of two G alpha protein subunits in Dictyostelium.
The Journal of biological chemistry - 15 Jan 1991
Kumagai A, Hadwiger J A, Pupillo M, Firtel R A
Abstract excerpt
In Dictyostelium, chemotaxis to folate during growth and cAMP during aggregation is controlled via cell surface receptors. To study the role of two G alpha proteins (G alpha 1 and G alpha 2) in these responses, we examined the physiological and biochemical effects of null mutations caused by antisense mutagenesis and gene disruptions. Disruption of G alpha 2 results in an aggregation-deficient phenotype and a...
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