Article

Macrophage chemotaxis steered by complex self-generated gradients of complement C5a

2025-11-06

Abstract excerpt

Macrophages rely on efficient chemotaxis to locate sites of infection and tissue damage. One general strategy that enhances chemotactic accuracy is the use of self-generated gradients, where cells locally deplete attractants to create or sharpen guidance cues. Here we show that mouse bone marrow–derived macrophages (BMDMs) migrate toward the complement component C5a using this strategy. Cells actively deplete C5a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a035ddc1-1d6e-560a-8571-452161f76d2b
DOI: 10.1101/2025.11.05.686842

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophage chemotaxis steered by complex self-generated gradients of complement C5aDOI 10.1101/2025.11.05.686842Read

The C3-C3aR axis modulates trained immunity in alveolar macrophagesSemantic proximity Read

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.Semantic proximity Read

Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR SignalingSemantic proximity Read

Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal.Semantic proximity Read

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1Semantic proximity Read

Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammationSemantic proximity Read

Intravascular Crawling of Patrolling Monocytes: A Lèvy-Like Motility for Unique Search Functions?Semantic proximity Read

The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxisSemantic proximity Read

Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNASemantic proximity Read

Signaling dynamics distinguish high and low priority neutrophil attractant receptorsSemantic proximity Read

Chemokine Receptors and Phagocyte Biology in ZebrafishSemantic proximity Read

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injurySemantic proximity Read