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Article

CHO glycosylation mutants: proteoglycans.

Methods in enzymology - 1 Jan 2006

Zhang Lijuan, Lawrence Roger, Frazier Beth A, Esko Jeffrey D

Abstract excerpt

Most glycosaminoglycan (GAG)-defective mutants have been isolated and characterized from Chinese hamster ovary (CHO) cells. Wild-type and GAG-defective CHO cells have been used by several hundreds of laboratories to study how altering the GAG structure of proteoglycans affects fundamental properties of cells, such as bacterial/viral infection, signaling, protein degradation, and cell adhesion. This chapter...

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PMID: 17113868
DOI: 10.1016/S0076-6879(06)16013-9

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