Article
Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.
Protein science : a publication of the Protein Society - 1 Jan 2004
Podust Larissa M, Bach Horacio, Kim Youngchang, Lamb David C, Arase Miharu, Sherman David H, Kelly Steven L, Waterman Michael R
Abstract excerpt
The genus Streptomyces produces two-thirds of microbially derived antibiotics. Polyketides form the largest and most diverse group of these natural products. Antibiotic diversity of polyketides is generated during their biosynthesis by several means, including postpolyketide modification performed by oxidoreductases, a broad group of enzymes including cytochrome P450 monooxygenases (CYPs). CYPs catalyze...
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