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<i>Streptomyces</i>cytochromes P450: applications in drug metabolism

6 Jun 2013

Abstract excerpt

INTRODUCTION: The biotransformation of drugs is critical in assessing safety and efficacy prior to human use. Cytochrome P450 (CYP; P450) enzymes are major enzymes involved in drug metabolism and bioactivation. In general, animal model systems are widely used to evaluate drug candidate toxicity and metabolism. Streptomyces strains have also been used for the metabolism of drugs screening prior to use in human...

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PMID: 23738914
DOI: 10.1517/17425255.2013.806485

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