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Article

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.

Applied microbiology and biotechnology - 1 Jul 2013

Kim Dong Hwan, Ryu Jeoung Hyun, Lee Keum Soon, Lee Bo Mi, Lee Mi Ok, Lim Si-Kyu, Maeng Pil Jae

Abstract excerpt

Tacrolimus (FK506) is an important macrocyclic polyketide showing antifungal and immunosuppressive activities, as well as neuroregenerative properties. Tacrolimus biosynthetic machinery should incorporate the shikimate-derived 4,5-dihydroxycyclohex-1-enecarboxylic acid (DHCHC) as a biosynthetic starter unit into the biosynthetic line of tacrolimus. fkbO is a homologue of rapK encoding chorismatase related to the...

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PMID: 23392766
DOI: 10.1007/s00253-013-4716-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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