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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in <i>Streptomyces ambofaciens</i>

28 Mar 2011

Abstract excerpt

There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other major life-threatening conditions. The recent development of genomics-guided approaches for novel natural product discovery has stimulated renewed interest in the search for natural product-based drugs. Genome sequence analysis of Streptomyces ambofaciens ATCC23877 has revealed numerous secondary metabolite...

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PMID: 21444795
DOI: 10.1073/pnas.1019077108

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