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Article

Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412.

Journal of industrial microbiology & biotechnology - 1 Oct 2012

Kim Dongju, Nah Ji-Hye, Choi Si-Sun, Shin Hwa Sung, Sherman David H, Kim Eung-Soo

Abstract excerpt

Tautomycetin (TMC), originally isolated from Streptomyces griseochromogenes, has been reported to possess biological functions including T cell-specific immunosuppressive and anticancer activities through a mechanism of differential inhibition of protein phosphatases such as PP1, PP2A, and SHP2. Independently isolated Streptomyces sp. CK4412 was also reported to produce a structurally identical TMC compound....

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PMID: 22733296
DOI: 10.1007/s10295-012-1157-2

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