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StreptomycesCytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents

19 Dec 2018

Abstract excerpt

The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed unusually large numbers of cytochrome P450 genes, which are involved in the biosynthesis of secondary metabolites. Many macrolide biosynthetic pathways are catalyzed by a series of enzymes in gene clusters...

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PMID: 30562877
DOI: 10.4062/biomolther.2018.183

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