Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Analysis of T Cell Intrinsic Roles of E2A by Conditional Gene Disruption in the Thymus

1 Apr 2002

Abstract excerpt

The importance of E2A transcription factors in T cell development has been demonstrated in studies of E2A-deficient mice, which display abnormal T cell development and a high frequency of T cell lymphomas. Because E2A expression is not restricted to the T cell lineage, the primary cause of the T cell phenotype in E2A-deficient mice was not fully determined. To further investigate the role of E2A in T cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Immune Cell Function and Interaction
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11937548
DOI: 10.4049/jimmunol.168.8.3923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Analysis of T Cell Intrinsic Roles of E2A by Conditional Gene Disruption in the ThymusPMID 11937548Read ↗

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Semantic proximity Read ↗

Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.Semantic proximity Read ↗

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell LymphomasSemantic proximity Read ↗

The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development.Semantic proximity Read ↗

E2A proteins enforce a proliferation checkpoint in developing thymocytes.Semantic proximity Read ↗

E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.Semantic proximity Read ↗

A tamoxifen inducible knock-in allele for investigation of E2A function.Semantic proximity Read ↗

Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemiaSemantic proximity Read ↗

Functional replacement of the mouse E2A gene with a human HEB cDNA.Semantic proximity Read ↗

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.Semantic proximity Read ↗

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Semantic proximity Read ↗

High incidence of thymic epithelial tumors in E2F2 transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.