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Article

Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002

Engel Isaac, Murre Cornelis

Abstract excerpt

The helix-loop-helix proteins E47 and E12, which are encoded by the E2A gene, regulate several stages of T cell development. In addition, mice deficient for E2A are highly susceptible to thymic lymphoma. Here we report that the development of lymphoma in E2A-deficient mice did not require pre- and recombinase-activating gene expression. Rather, we found that, whereas illegitimate DNA rearrangement did not play a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12172006
DOI: 10.1073/pnas.162373999
PMCID: PMC123255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.PMID 12172006Read ↗

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