Cell cycle regulatory molecular profiles of pediatric T-cell lymphoblastic leukemia and lymphoma.

Abstract excerpt

Proper regulation of the cell cycle plays a fundamental role in any organism, as it impacts cellular division, differentiation and death. In this intricate process, progression through the phases of the cell cycle relies on various cyclin-cyclin-dependent kinase protein complexes that are regulated by multiple cyclin-dependent kinase inhibitors. Ultimately, the transcription factor E2F is influenced by this...

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