Article
High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.
Molecular and cellular biology - 1 Dec 1997
Yan W, Young A Z, Soares V C, Kelley R, Benezra R, Zhuang Y
Abstract excerpt
The basic-helix-loop-helix (bHLH) proteins encoded by the E2A gene are broadly expressed transcription regulators which function through binding to the E-box enhancer sequences. The DNA binding activities of E2A proteins are directly inhibited upon dimerization with the Id1 gene product. It has b...
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