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Article

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.

Immunity - 16 May 2017

Miyazaki Masaki, Miyazaki Kazuko, Chen Kenian, Jin Yi, Turner Jacob, Moore Amanda J, Saito Rintaro, Yoshida Kenichi, Ogawa Seishi, Rodewald Hans-Reimer, Lin Yin C, Kawamoto Hiroshi, Murre Cornelis

Abstract excerpt

Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant...

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Identifiers

PMID: 28514688
DOI: 10.1016/j.immuni.2017.04.022
PMCID: PMC5512722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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