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Article

Mining for SNPs: putting the common variants--common disease hypothesis to the test.

Pharmacogenomics - 1 Feb 2000

Cargill M, Daley G Q

Abstract excerpt

Classical molecular genetic strategies have succeeded in identifying mutations responsible for numerous rare diseases with Mendelian patterns of inheritance, but have been largely unsuccessful in unravelling the (genetic basis of complex medical conditions like cardiovascular disease' diabetes and mental illness. These common disorders are shaped by multiple genes that exert weak allelic effects in the setting of...

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PMID: 11258594
DOI: 10.1517/14622416.1.1.27

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