Article
Haplotype tagging for the identification of common disease genes.
Nature genetics - 1 Oct 2001
Johnson G C, Esposito L, Barratt B J, Smith A N, Heward J, Di Genova G, Ueda H, Cordell H J, Eaves I A, Dudbridge F, Twells R C, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough S C, Clayton D G, Todd J A
Abstract excerpt
Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping effort and cost of producing such an LD map could be reduced. Although different metrics that measure the extent of LD have been evaluated, even the most recent studies have not placed significant emphasis on the...
Topics
- Base Sequence
- DNA
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Sequence Homology, Nucleic Acid