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Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans.

Nature genetics - 1 Apr 2003

Carlson Christopher S, Eberle Michael A, Rieder Mark J, Smith Joshua D, Kruglyak Leonid, Nickerson Deborah A

Abstract excerpt

More than 5 million single-nucleotide polymorphisms (SNPs) with minor-allele frequency greater than 10% are expected to exist in the human genome. Some of these SNPs may be associated with risk of developing common diseases. To assess the power of currently available SNPs to detect such associations, we resequenced 50 genes in two ethnic samples and measured patterns of linkage disequilibrium between the subset...

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PMID: 12652300
DOI: 10.1038/ng1128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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