Article
Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor.
The Journal of biological chemistry - 27 Apr 2001
Zuscik M J, Chalothorn D, Hellard D, Deighan C, McGee A, Daly C J, Waugh D J, Ross S A, Gaivin R J, Morehead A J, Thomas J D, Plow E F, McGrath J C, Piascik M T, Perez D M
Abstract excerpt
alpha(1)-Adrenergic receptors (alpha(1A), alpha(1B), and alpha(1D)) are regulators of systemic arterial blood pressure and blood flow. Whereas vasoconstrictory action of the alpha(1A) and alpha(1D) subtypes is thought to be mainly responsible for this activity, the role of the alpha(1B)-adrenergic receptor (alpha(1B)AR) in this process is controversial. We have generated transgenic mice that overexpress either...
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