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Article

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice.

Disease models & mechanisms - 1 Nov 2015

González-Núñez María, Riolobos Adela S, Castellano Orlando, Fuentes-Calvo Isabel, de los Ángeles Sevilla María, Oujo Bárbara, Pericacho Miguel, Cruz-Gonzalez Ignacio, Pérez-Barriocanal Fernando, ten Dijke Peter, López-Novoa Jose M

Abstract excerpt

The activin receptor-like kinase 1 (ALK-1) is a type I cell-surface receptor for the transforming growth factor-β (TGF-β) family of proteins. Hypertension is related to TGF-β1, because increased TGF-β1 expression is correlated with an elevation in arterial pressure (AP) and TGF-β expression is upregulated by the renin-angiotensin-aldosterone system. The purpose of this study was to assess the role of ALK-1 in...

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Share to Activin Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26398936
DOI: 10.1242/dmm.019695
PMCID: PMC4631783

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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