Article
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.
Circulation - 4 Jan 2005
Sidhu Jasvinder S, Rajawat Yadavendra S, Rami Tapan G, Gollob Michael H, Wang Zhinong, Yuan Ruiyong, Marian A J, DeMayo Francesco J, Weilbacher Donald, Taffet George E, Davies Joanna K, Carling David, Khoury Dirar S, Roberts Robert
Abstract excerpt
BACKGROUND: We identified a gene (PRKAG2) that encodes the gamma-2 regulatory subunit of AMP-activated protein kinase (AMPK) with a mutation (Arg302Gln) responsible for familial Wolff-Parkinson-White (WPW) syndrome. The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy. METHODS AND RESULTS: To elucidate the molecular basis for the phenotype, transgenic mice...
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