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Article

Altering the RNA-binding mode of the U1A RBD1 protein.

Journal of molecular biology - 9 Jan 2004

Showalter Scott A, Hall Kathleen B

Abstract excerpt

The N-terminal RNA-binding domain (RBD1) of the human U1A protein is evolutionarily designed to bind its RNA targets with great affinity and specificity. The physical mechanisms that modulate the coupling (local cooperativity) among amino acid residues on the extensive binding surface of RBD1 are investigated here, using mutants that replace a highly conserved glycine residue. This glycine residue, at the...

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Source

Identifiers

PMID: 14672656
DOI: 10.1016/j.jmb.2003.10.055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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