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Article

Unraveling the Allosteric Mechanism of Four Cancer-related Mutations in the Disruption of p53-DNA Interaction.

The journal of physical chemistry. B - 16 Sept 2021

Tang Yiming, Yao Yifei, Wei Guanghong

Abstract excerpt

The p53 protein plays active roles in the physiological regulation of cell cycle as well as in cancer developments. In more than half of human cancers, the protein is inactivated by mutations located primarily in its DNA-binding domain (DBD), and some mutations located in the β-sandwich region of DBD are reported to decrease p53-DNA binding affinities. To understand the long-range correlation between p53...

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Identifiers

PMID: 34403252
DOI: 10.1021/acs.jpcb.1c05638

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