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Investigation of Structural Mechanisms Underlying p53 Dysfunction Caused by 148 Missense Mutations Using AlphaFold3 and Molecular Dynamics Simulations

4 Jun 2025

Abstract excerpt

Tumor protein p53 (TP53) is a crucial regulator of genomic integrity, frequently mutated in more than half of all human cancers. These mutations predominantly target the DNA-binding domain (DBD), impairing p53's interaction with DNA and its tumor-suppressive functions. To elucidate the structural and functional consequences of p53 mutations, we investigated 148 missense variants located within its DNA-binding...

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PMID: 40464633
DOI: 10.1021/acs.jcim.5c00580

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