Unraveling the allosteric mechanism and mechanical stability of partial and complete loss-of-function mutations in p53 DNA-binding domain.

Abstract excerpt

Mutations in functional proteins are the core cause of protein misfolding and dysfunction. Different mutation types exert distinct effects on protein structure and function, thus determining the specificity and diversity of targeted therapeutic strategies. In this study, we took the tumor suppressor protein p53 as a model to investigate the impacts of different mutation types on protein structure and function....

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