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Article

U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.

Biopolymers - 1 Sept 2011

Kormos Bethany L, Pieniazek Susan N, Beveridge David L, Baranger Anne M

Abstract excerpt

Molecular dynamics (MD) simulations were carried out to compare the free and bound structures of wild type U1A protein with several Phe56 mutant U1A proteins that bind the target stem loop 2 (SL2) RNA with a range of affinities. The simulations indicate the free U1A protein is more flexible than the U1A-RNA complex for both wild type and Phe56 mutant systems. A complete analysis of the hydrogen-bonding (HB) and...

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Identifiers

PMID: 21384338
DOI: 10.1002/bip.21616
PMCID: PMC3732173

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Source receipt: pubmed, retrieved 7 Sept 2026.

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