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Article

Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain.

Journal of molecular biology - 23 Jul 2021

Schrag Lynn G, Liu Xiaorong, Thevarajan Indhujah, Prakash Om, Zolkiewski Michal, Chen Jianhan

Abstract excerpt

Intrinsically disordered proteins (IDPs) are key components of regulatory networks that control crucial aspects of cell decision making. The intrinsically disordered transactivation domain (TAD) of tumor suppressor p53 mediates its interactions with multiple regulatory pathways to control the p53 homeostasis during the cellular response to genotoxic stress. Many cancer-associated mutations have been discovered in...

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Identifiers

PMID: 33984364
DOI: 10.1016/j.jmb.2021.167048
PMCID: PMC8286338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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