Article
A random variance model for detection of differential gene expression in small microarray experiments.
Bioinformatics (Oxford, England) - 12 Dec 2003
Wright George W, Simon Richard M
Abstract excerpt
MOTIVATION: Microarray techniques provide a valuable way of characterizing the molecular nature of disease. Unfortunately expense and limited specimen availability often lead to studies with small sample sizes. This makes accurate estimation of variability difficult, since variance estimates made on a gene by gene basis will have few degrees of freedom, and the assumption that all genes share equal variance is...
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