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Article

A full Bayesian hierarchical mixture model for the variance of gene differential expression.

BMC bioinformatics - 17 Apr 2007

Manda Samuel O M, Walls Rebecca E, Gilthorpe Mark S

Abstract excerpt

BACKGROUND: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccurate. Visual inspection of graphical summaries of these data usually reveals that heteroscedasticity is present, and the standard approach to address this is to take a log2 transformation. In such circumstances, it is then common to...

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PMID: 17439644
DOI: 10.1186/1471-2105-8-124
PMCID: PMC1876253

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