Article

Robust identification of regulatory variants (eQTLs) using a differential expression framework developed for RNA-sequencing

2022-11-18

Abstract excerpt

<h4>Background</h4> A gap currently exists between genetic variants and the underlying cell and tissue biology of a trait, and expression quantitative trait loci (eQTL) studies provide important information to help close that gap. However, two concerns that arise with eQTL analyses using RNA-sequencing data are normalization of data across samples and the data not following a normal distribution. Multiple pipelin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c2b0fdd-22a0-56f7-9519-a2250fd06971
DOI: 10.1101/2022.11.18.517114

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust identification of regulatory variants (eQTLs) using a differential expression framework developed for RNA-sequencingDOI 10.1101/2022.11.18.517114Read

A systematic comparison of normalization methods for eQTL analysis.Semantic proximity Read

Introductory Methods for eQTL Analyses.Semantic proximity Read

Quantifying genetic regulatory variation in human populations improves transcriptome analysis in rare disease patientsSemantic proximity Read

Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA–sequencing dataSemantic proximity Read

ReQTL – an allele-level measure of variation-expression genomic relationshipsSemantic proximity Read

DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.Semantic proximity Read

eQTL studies: from bulk tissues to single cells.Semantic proximity Read

The GTEx Consortium atlas of genetic regulatory effects across human tissuesSemantic proximity Read

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.Semantic proximity Read

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.Semantic proximity Read

Where Are the Disease-Associated eQTLs?Semantic proximity Read

An alternative framework for transcriptome-wide association studies to detect and decipher gene-trait associationsSemantic proximity Read